Drug Resistance

Emergence of resistance to antimalarial drugs has become a major hurdle in the successful treatment of the infection, and has contributed significantly to global malaria-related mortality.[1] Till date, drug resistance has been documented in P. falciparum, P. vivax, and P. malariae.[1] P. falciparum has developed resistance to nearly all antimalarial…

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Antimalarial Drugs

Mother Nature gave us the cinchona alkaloids and qinghaosu. World War II led to the introduction of chloroquine, chloroguanide (proguanil), and eventually amodiaquine and pyrimethamine. The war in Vietnam brought mefloquine and halofantrine. These drugs are all we have available now to treat malaria. It is difficult to see where…

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